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Persistent central nervous system effects of an adverse early environment: clinical and preclinical studies

โœ Scribed by David A. Gutman; Charles B. Nemeroff


Book ID
117198091
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
180 KB
Volume
79
Category
Article
ISSN
0031-9384

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BACKGROUND. Preventive cranial radiotherapy (CRT) in childhood acute lymphoblastic leukemia (ALL), although effective, may be associated with neurologic sequelae and second malignancies. Attempts to replace CRT with intensified intrathecal therapy (IT) have shown promise in lower risk subgroups. In