Effective preventive central nervous system therapy with extended triple intrathecal therapy and the modified ALL-BFM 86 chemotherapy program in an enlarged non-high risk group of children and adolescents with non-B-cell acute lymphoblastic leukemia : The ISRAEL National Study report
✍ Scribed by Batia Stark; Rivka Sharon; Gideon Rechavi; Dina Attias; Ami Ballin; Gabriel Cividalli; Yoav Burstein; Dalia Sthoeger; Ayala Abramov; Rina Zaizov
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 145 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
BACKGROUND. Preventive cranial radiotherapy (CRT) in childhood acute lymphoblastic leukemia (ALL), although effective, may be associated with neurologic sequelae and second malignancies. Attempts to replace CRT with intensified intrathecal therapy (IT) have shown promise in lower risk subgroups. In the Israel National Study (INS) 89 trial, the efficacy of extended triple IT (TIT) alone for cranial prophylaxis in an enlarged non-high risk group (Non-HRG) was assessed in the context of a modified ALL-Berlin-Frankfurt-Munster (BFM) systemic chemotherapy program.