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Persistence of Collagen Type II-Specific T-Cell Clones in the Synovial Membrane of a Patient with Rheumatoid Arthritis

✍ Scribed by Marco Londei, Corinne M. Savill, Adrienne Verhoef, Fionula Brennan, Zoe A. Leech, Victor Duance, Ravinder N. Maini and Marc Feldmann


Book ID
123636510
Publisher
National Academy of Sciences
Year
1989
Tongue
English
Weight
804 KB
Volume
86
Category
Article
ISSN
0027-8424

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Objective. To characterize and clone T cells specific for type II collagen (CII) in a patient with relapsing polychondritis (RP) and to establish whether the immunodominant epitope of CII determined in HLA transgenic mice is used in the human autoimmune response to CII. Methods. T cell responses to