Persistence of Collagen Type II-Specific T-Cell Clones in the Synovial Membrane of a Patient with Rheumatoid Arthritis
β Scribed by Marco Londei, Corinne M. Savill, Adrienne Verhoef, Fionula Brennan, Zoe A. Leech, Victor Duance, Ravinder N. Maini and Marc Feldmann
- Book ID
- 123636510
- Publisher
- National Academy of Sciences
- Year
- 1989
- Tongue
- English
- Weight
- 804 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/33180
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π SIMILAR VOLUMES
Production of antibodies to IgG and to type I and type I1 collagen (CI and CII) was analyzed by enzymelinked immunospot assay in patients with rheumatoid arthritis (RA) and patients with other inflammatory or degenerative joint diseases. Anti-CII-secreting cells, generally in high numbers, were foun
Objective. To characterize and clone T cells specific for type II collagen (CII) in a patient with relapsing polychondritis (RP) and to establish whether the immunodominant epitope of CII determined in HLA transgenic mice is used in the human autoimmune response to CII. Methods. T cell responses to