Persistence of a component of DNA methylation in gastric mucosae afterHelicobacter pylorieradication
β Scribed by Takeshi Nakajima; Shotaro Enomoto; Satoshi Yamashita; Takayuki Ando; Yukihiro Nakanishi; Kazuyuki Nakazawa; Ichiro Oda; Takuji Gotoda; Toshikazu Ushijima
- Book ID
- 106180568
- Publisher
- Springer Japan
- Year
- 2009
- Tongue
- English
- Weight
- 370 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0944-1174
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## Abstract Aberrant DNA methylation is deeply involved in human cancers, but its inducers and targets are still mostly unclear. __Helicobacter pylori__ infection was recently shown to induce aberrant methylation in gastric mucosae, and produce a predisposed field for cancerization. Here, we analyz
## Abstract Accumulation of aberrant DNA methylation in normalβappearing gastric mucosae, mostly induced by __H. pylori__ infection, is now known to be deeply involved in predisposition to gastric cancers (epigenetic field defect), and silencing of proteinβcoding genes has been analyzed so far. In