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DNA methylation of interferon regulatory factors in gastric cancer and noncancerous gastric mucosae

✍ Scribed by Masaki Yamashita; Minoru Toyota; Hiromu Suzuki; Masanori Nojima; Eiichiro Yamamoto; Seiko Kamimae; Yoshiyuki Watanabe; Masahiro Kai; Hirofumi Akashi; Reo Maruyama; Yasushi Sasaki; Hiroo Yamano; Tamotsu Sugai; Yasuhisa Shinomura; Kohzoh Imai; Takashi Tokino; Fumio Itoh

Book ID: 108586745
Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 858 KB
Volume: 101
Category: Article
ISSN: 1347-9032
DOI: 10.1111/j.1349-7006.2010.01581.x

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## Abstract Accumulation of aberrant DNA methylation in normal‐appearing gastric mucosae, mostly induced by __H. pylori__ infection, is now known to be deeply involved in predisposition to gastric cancers (epigenetic field defect), and silencing of protein‐coding genes has been analyzed so far. In