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Persistence and load of high-risk HPV are predictors for development of high-grade cervical lesions: A longitudinal French cohort study

✍ Scribed by Véronique Dalstein; Didier Riethmuller; Jean-Luc Prétet; Karine Le Bail Carval; Jean-Loup Sautière; Jean-Pierre Carbillet; Bernadette Kantelip; Jean-Patrick Schaal; Christiane Mougin

Book ID
102271501
Publisher
John Wiley and Sons
Year
2003
Tongue
French
Weight
110 KB
Volume
106
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Oncogenic HPV types are the major cause of worldwide cervical cancer, but only a small proportion of infected women will develop high‐grade cervical intraepithelial neoplasia or cancer (CIN2/3+). We performed a prospective study including 781 women with normal, atypical squamous cells of undetermined significance (ASCUS) or low‐grade squamous intraepithelial lesion (LGSIL) cytology, and infected or not by high‐risk (HR) HPV tested by Hybrid Capture II. Women were followed up every 6 months for a median period of 22 months. Among the HR‐HPV‐positive women at entry, more than half cleared their virus in 7.5 months; the clearance rate was greater for low viral loads than for high loads and also was higher in women with an initial ASCUS/LGSIL smear than in women with normal cytology. The incidence of cytologic abnormalities strongly depended on baseline viral load and HR‐HPV persistence. Maintenance of cytologic abnormalities was associated with the outcome of HR‐HPV status (negative

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