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Human papillomavirus genotype as a predictor of persistence and development of high-grade lesions in women with minor cervical abnormalities

✍ Scribed by Philip Londesborough; Linda Ho; George Terry; Jack Cuzick; Cosette Wheeler; Albert Singer

Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
639 KB
Volume
69
Category
Article
ISSN
0020-7136

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✦ Synopsis

Women referred for colposcopy with mild and moderate dyskaryosis and found to have only minor cervical abnormalities were screened for oncogenic human papilloma virus (HPV) types. The natural development of these abnormalities in 42 HPV-positive women was assessed by cytology and colposcopy at 6-month intervals for up to 2 years. As is the case with cancers and high-grade cervical intra-epithelial neoplasia (CIN), minor cervical abnormalities were frequently found to be associated with HPV16, -18, -3 I and -33. Viral persistence and the development of high-grade lesions were found to be closely associated with HPVl6; 56% of HPV16 isolates were persistent compared to 7% of other HPV types, and all 4 subsequent CIN 3 lesions were in women with persistent infection. A striking association of persistence with a variant of HPVl6 having a base change at nucleotide 350 was observed. Ten of I 2 women with this variant had persistent infection compared to only I of 16 women infected with the HPV I6 prototype.

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