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Peroxisome proliferator-activated receptorα (PPARα) agonists down-regulate α2-macroglobulin expression by a PPARα-dependent mechanism

✍ Scribed by María del Carmen González; J. Christopher Corton; Russell C. Cattley; Emilio Herrera; Carlos Bocos

Book ID: 116309082
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 398 KB
Volume: 91
Category: Article
ISSN: 0300-9084
DOI: 10.1016/j.biochi.2009.05.007

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## Abstract Peroxisome proliferator‐activated receptor alpha (PPARα) is a member of the nuclear hormone receptor superfamily that can be activated by natural fatty acids and various xenobiotics, including clofibrate. This transcription factor primarily regulates genes involved in lipid metabolism a