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Phytol directly activates peroxisome proliferator-activated receptor α (PPARα) and regulates gene expression involved in lipid metabolism in PPARα-expressing HepG2 hepatocytes

✍ Scribed by Tsuyoshi Goto; Nobuyuki Takahashi; Sota Kato; Kahori Egawa; Shogo Ebisu; Tatsuya Moriyama; Tohru Fushiki; Teruo Kawada


Book ID
116291477
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
173 KB
Volume
337
Category
Article
ISSN
0006-291X

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## Abstract **Scope:** Peroxisome proliferator‐activated receptor‐α (PPARα) is a key regulator of circulating lipid level. Thus, various food‐derived compounds that activate PPARα as agonists have been screened and characterized. **Methods and results:** We investigated the effects of auraptene, a