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Peroxisomal beta-oxidation enzyme gene expression in the developing mouse brain

✍ Scribed by Anja Knoll; Jérôme Salles; Françoise Sargueil; Claude Cassagne; Bertrand Garbay

Book ID
117470732
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
181 KB
Volume
285
Category
Article
ISSN
0304-3940

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Thioridazine, an inhibitor of peroxisomal beta-oxidation, was administered orally to nursing rats during the period of maximal myelination in the pups (8-21 days postnatally). Under the experimental conditions, thioridazine causes accumulation of C24 and C26 fatty acids in pup brain lipids, an effec