✦ LIBER ✦

Inhibition of peroxisomal beta-oxidation and brain development in rats

✍ Scribed by Christiane Van Den Branden; Georges Dacremont; Robert Hooghe; Frank Roels

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 608 KB
Volume: 2
Category: Article
ISSN: 0894-1491
DOI: 10.1002/glia.440020407

No coin nor oath required. For personal study only.

✦ Synopsis

Thioridazine, an inhibitor of peroxisomal beta-oxidation, was administered orally to nursing rats during the period of maximal myelination in the pups (8-21 days postnatally). Under the experimental conditions, thioridazine causes accumulation of C24 and C26 fatty acids in pup brain lipids, an effect we consider to be a typical consequence of inhibited peroxisomal beta-oxidation. In the corpus callosum of treated pups, the relationship between axon diameter and myelin sheath thickness is altered compared with matched controls. Thioridazine also induces undernourishment effects in 21 day-old rats. Body and brain weight are severely reduced. Liver peroxisomes show a starvation-type metabolism. Undernourishment is known to influence myelination in developing rat brain. However, known consequences of undernourishment, such as decreased myelin concentration in whole brain, decreased percentage of myelinated fibers, and decreased granule-to-Purkinje cell ratio are not present.

📜 SIMILAR VOLUMES

Experimental inhibition of peroxisomal β

Experimental inhibition of peroxisomal β-oxidation in rats: Influence on brain myelination

✍ Christiane Van Den Branden; Jan Leeman; Georges Dacremont; Robert Collumbien; Fr 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 598 KB

Oral administration of thioridazine, an inhibitor of perox tsomal p-oxidation, to normal rats from weaning till day 60 causes a small increase of the very long chain fatty acid C26 in brain lipids. Myelination in the brain is decreased. In the genu of the corpus callosum the ratio of non-myelinatedm

Postnatal development of peroxisomal and

Postnatal development of peroxisomal and mitochondrial enzymes in rat liver

✍ Jeffrey B. Krahling; Robert Gee; John A. Gauger; N. E. Tolbert 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 English ⚖ 947 KB

## Abstract Subcellular organelles from livers of rats three days prenatal to 50 weeks postnatal were separated on sucrose gradients. The peroxisomes had a constant density of 1.243 g/ml throughout the life of the animal. The density of the mitochondria changed from about 1.236 g/ml at birth to a c

Inhibition of phosphatidylserine biosynt

Inhibition of phosphatidylserine biosynthesis in developing rat brain by maternal exposure to ethanol

✍ Zhiming Wen; Hee-Yong Kim 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 498 KB 👁 1 views

## Abstract Phosphatidylserine (PtdSer), major acidic phospholipids in neuronal membranes, participate in important cell signaling processes. The PtdSer in brain is highly enriched with docosahexaenoic acid (DHA; 22:6n‐3), and the DHA status or ethanol exposure has been shown to influence the PtdSe

Enhanced peroxisomal β-oxidation of fatt

Enhanced peroxisomal β-oxidation of fatty acids and glutathione metabolism in rats exposed to phenoxyacetic acids

✍ Eino Hietanen; Markku Ahotupa; Tuula Heinonen; Heli Hämäläinen; Tarja Kunnas; Ka 📂 Article 📅 1985 🏛 Elsevier Science 🌐 English ⚖ 548 KB

Anticonvulsant activity and selective in

Anticonvulsant activity and selective inhibition of NAD-dependent oxidations in rat brain homogenates by newer mercaptotriazoles

✍ Surendra S. Parmar; Mahima Chaudhary; Sunil K. Chaudhary; Sushil Kumar; Herzl R. 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 English ⚖ 553 KB

Eight l-(2,6-dimethylphenoxyacetyl)-4-(substituted phe-ny1)thiosemicarbazides were cyclized to the corresponding 5-(2,6-dimethylphenoxymethyl)-4-(substituted phenyl)-3-mercapto-l,2,-4(4H)-triazoles and 5-(2,6-dimethylphenoxymethyl)-4-(substituted phenyl)-3-[ 1,2,4(4H)-triazolethioglycolic] acids. Th

Localization of mRNAs for adrenoleukodys

Localization of mRNAs for adrenoleukodystrophy and the 70 kDa peroxisomal (PMP70) proteins in the rat brain during post-natal development

✍ H. Pollard; J. Moreau; P. Aubourg 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 589 KB

Adrenoleukodystrophy (ALD) is a genetic demyelinating disorder caused by the mutation of a gene encoding a 75-kDa peroxisomal protein (ALDP) that belongs to the superfamily of ATP binding casette (ABC) transporters. The PMP 70 gene codes for another peroxisomal ABC transporter that shows 38.5% amino