Experimental inhibition of peroxisomal β-oxidation in rats: Influence on brain myelination

✍ Scribed by Christiane Van Den Branden; Jan Leeman; Georges Dacremont; Robert Collumbien; Frank Roels

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 598 KB
• Volume: 3
• Category: Article
• ISSN: 0894-1491
• DOI: 10.1002/glia.440030604

✦ Synopsis

Oral administration of thioridazine, an inhibitor of perox tsomal p-oxidation, to normal rats from weaning till day 60 causes a small increase of the very long chain fatty acid C26 in brain lipids. Myelination in the brain is decreased. In the genu of the corpus callosum the ratio of non-myelinatedmyelinated axons is increased. In the commissura anterior the myelin sheaths of the axons are significantly thinner in treated than in control animals. Undernourishment caused by the drug is minimal in this experiment. Area and total DNA of glial nuclei are unaltered in both the genu and the commissura anterior of treated rats. The distribution of chromatin (texture), however, shows small differences in the corpus callosum.