Mouse islets were used to study how glucose modulates arginine stimulation of insulin release. At 3 mmol/l glucose, arginine (20 mmol/l) decreased the resting membrane potential of B cells by about 10 mV, but did not evoke electrical activity. This depolarisation was accompanied by a slight but rapi
Permissive effect of glucose on the glucagon-induced accumulation of cAMP in isolated rat pancreatic islets
โ Scribed by P. Schauder; J. Arends; B. Schindler; R. Ebert; H. Frerichs
- Publisher
- Springer
- Year
- 1977
- Tongue
- English
- Weight
- 498 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0012-186X
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๐ SIMILAR VOLUMES
Pancreatic B-cell calcium as histochemically detectable with glyoxal bis (2-hydroxyanil)=GBHA was studied in isolated islets of fed rats. GBHA has previously been shown by us to detect an ionized or readily ionizable Ca-fraction (GBHA-Ca). In the presence of Ca + + (2.5 raM), high glucose (15 raM) i
In pancreatic islets prepared from fed rats and incubated at a low concentration (1 . 7 mM) of D-glucose, D-mannoheptulose (10 . 0 mM) virtually fails to aect the metabolism of the hexose. Likewise, in islets from starved rats, the relative extent of the inhibitory action of D-mannoheptulose upon D-