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Permeabilization of the Mitochondrial Inner Membrane by Short Cecropin-A–Melittin Hybrid Peptides

✍ Scribed by Pilar Díaz-Achirica; Susana Prieto; Josep Ubach; David Andreu; Eduardo Rial; Luis Rivas


Book ID
115131049
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
764 KB
Volume
224
Category
Article
ISSN
1432-1327

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A 15-residue hybrid peptide ( KWKLFKKIGAVLKVL-amide) incorporating partial sequences of cecropin A and melittin causes the release of carboxyfluoresceine encapsulated in phosphatidylcholine liposomes. Succinylation of the amino groups in the N-terminus and lysine side chains inhibits the effect of t