Investigation of transport mechanism of
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Toyofumi Suzuki; Masakazu Oshimi; Kazuo Tomono; Manabu Hanano; Jun Watanabe
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Article
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2002
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John Wiley and Sons
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English
β 108 KB
π 1 views
To characterize pentazocine (PTZ) transport across the blood-brain barrier (BBB), the cerebrovascular permeability-surface area product (PS(inf)) of PTZ was determined by a well-established in situ rat brain perfusion technique. The uptake kinetics of PTZ by the rat brain exhibited saturability, whi