Kinetics of Amino Acid Transport at the Blood-Brain Barrier Studied Using an in Situ Brain Perfusion Technique
β Scribed by QUENTIN R. SMITH; YOSHIO TAKASATO
- Book ID
- 118723632
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 825 KB
- Volume
- 481
- Category
- Article
- ISSN
- 0890-6564
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π SIMILAR VOLUMES
To characterize pentazocine (PTZ) transport across the blood-brain barrier (BBB), the cerebrovascular permeability-surface area product (PS(inf)) of PTZ was determined by a well-established in situ rat brain perfusion technique. The uptake kinetics of PTZ by the rat brain exhibited saturability, whi
Neutral amino acid (NAA) transport across the blood-brain barrier was examined in pentobarbitalanesthetized rats with an in situ brain perfusion technique. Fourteen of 16 plasma NAAs showed measurable affinity for the cerebrovascular NAA transport system. Values of the transport constants (V,,,, K,,