✦ LIBER ✦

Perinatal infection and persistence of human papillomavirus types 16 and 18 in infants

✍ Scribed by John Cason; Jeremy N. Kaye; Richard J. Jewers; Parminder K. Kambo; Jon M. Bible; Barbara Kell; Bhavneet Shergill; Farzin Pakarian; K. Shanti Raju; Jennifer M. Best

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 1016 KB
Volume: 47
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890470305

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Perinatal transmission of genital human papillomaviruses (HPVs), including HPV‐16 and ‐18 which are associated with anogenital carcinomas have been described previously [Pakarian et al. (1994): British Journal of Obstetrics and Gynaecology 101:514‐517; Kaye et al. (1994) Journal of Medical Virology 44:415‐421]. A study was undertaken to investigate whether HPV‐16 and ‐18 DNA in infants contaminated at delivery persists until they are 6 months of age. Of 61 pregnant women recruited, 42 (68.8%) were HPV‐16 and 13 (21.3%) were HPV‐18 DNA positive. At 24 hr there were transmission rates from HPV DNA positive mothers to their infants of about 73% (HPV‐16: 69%; HPV‐18: 76.9%). Ten mothers who were both HPV‐16 and ‐18 DNA positive produced six (60%) infants who were also doubly positive at 24 hr. HPV DNA persisted to 6 weeks in 79.5% (HPV‐16: 84%; HPV‐18: 75%) of those infants who were positive at birth. At 6 months of age, persistent HPV‐16 DNA was detected in 83.3% of cases, but HPV‐18 DNA persistence at this time was 20%. To extend these observations over a greater age range of children HPV‐16 L1 and L2 proteins were expressed in insect cells via recombinant baculoviruses and sera from 229 children were examined to determine at what age IgM antibodies to HPV were acquired. There was a bimodal distribution of IgM seropositivity which peaked between 2 and 5 and 13 and 16 years of age, suggesting that two distinct modes of transmission may occur. The observation that infection with high cancer risk genital HPVs may occur in early life and persist is of considerable importance for HPV vaccine strategies. © Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Chlamydia trachomatis infection and pers

Chlamydia trachomatis infection and persistence of human papillomavirus

✍ Ilvars Silins; Walter Ryd; Anders Strand; Göran Wadell; Sven Törnberg; Bengt Gör 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 229 KB

## Abstract Human papillomavirus (HPV) persistence is the major cause of cervical cancer, but most HPV infections will not persist and risk factors for HPV persistence are not well known. __Chlamydia (C.) trachomatis__ infection seems to also be associated with cervical cancer. We investigated whet

High prevalence of human papillomavirus

High prevalence of human papillomavirus types 16 and 18 in middle-ear carcinomas

✍ Sen-Tien Tsai; Ching Li; Ying-Tai Jin; Wen-Yuan Chao; Ih-Jen Su 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 224 KB 👁 1 views

Chronic suppurative otitis media, averaging 20 or more years of duration, has been associated with cancer in this region in 40%-80% of cases. Although human papillomaviruses (HPV) have been implicated in many human squamous-cell neoplasms, their role in the pathogenesis of middle-ear malignancies re

Quantitative human papillomavirus 16 and

Quantitative human papillomavirus 16 and 18 levels in incident infections and cervical lesion development

✍ Rachel L. Winer; Tiffany G. Harris; Long Fu Xi; Kathrin U. Jansen; James P. Hugh 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 108 KB

## Abstract Human papillomavirus (HPV) RNA levels may be a more sensitive early indicator of predisposition to carcinogenesis than DNA levels. We evaluated whether levels of HPV‐16 and HPV‐18 DNA and messenger RNA (mRNA) in newly detected infections are associated with cervical lesion development.

Association between toll-like receptor e

Association between toll-like receptor expression and human papillomavirus type 16 persistence

✍ Ibrahim I. Daud; Mark E. Scott; Yifei Ma; Stephen Shiboski; Sepideh Farhat; Anna 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 676 KB

## Abstract The mechanisms involved in mucosal immune control of cervical human papillomavirus (HPV) infection remain ill defined. Because toll‐like receptors (TLRs) are key players in innate immune responses, we investigated the association between TLR expression and viral persistence or clearance

A survey of seroprevalence of human papi

A survey of seroprevalence of human papillomavirus types 16, 18 and 33 among children

✍ Veronika af Geijersstam; Carina Eklund; Zhaohui Wang; Martin Sapp; John T. Schil 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 72 KB 👁 1 views

The importance and natural history of HPV infections in childhood is incompletely understood. We performed a survey for presence of serum antibodies to HPV capsids among 1031 children aged 0 to 13 years, resident in Stockholm, Sweden. The HPV seroprevalence among these children was 3.0% for HPV16, 0

Expression of human papillomavirus types

Expression of human papillomavirus types 16 and 18 DNA sequences in cervical carcinoma cell lines

✍ Dr. Mary M. Pater; Alan Pater 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 616 KB

A total of six cervical carcinoma cell lines, of which two contained human papillomavirus (HPV) type 16 and four contained HPV type 18 DNA, were examined for viral RNA expression by spot-blot hybridization. All six cell lines contained HPV-specific cytoplasmic poly(A)-containing RNA. The same RNA sp