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Performance of an Iterative Two-stage Bayesian Technique for Population Pharmacokinetic Analysis of Rich Data Sets

✍ Scribed by Johannes H. Proost; Douglas J. Eleveld

Book ID: 106493114
Publisher: Springer US
Year: 2007
Tongue: English
Weight: 180 KB
Volume: 24
Category: Article
ISSN: 0724-8741
DOI: 10.1007/s11095-007-9261-0

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Simultaneous versus sequential pharmacokinetic-pharmacodynamic population analysis using an Iterative Two-Stage Bayesian technique

✍ Johannes H. Proost; Sjouke Schiere; Douglas J. Eleveld; J. Mark K. H. Wierda 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 231 KB

## Abstract A method for simultaneous pharmacokinetic‐pharmacodynamic (PK‐PD) population analysis using an Iterative Two‐Stage Bayesian (ITSB) algorithm was developed. The method was evaluated using clinical data and Monte Carlo simulations. Data from a clinical study with rocuronium in nine anest