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Performance of an Iterative Two-stage Bayesian Technique for Population Pharmacokinetic Analysis of Rich Data Sets

✍ Scribed by Johannes H. Proost; Douglas J. Eleveld


Book ID
106493114
Publisher
Springer US
Year
2007
Tongue
English
Weight
180 KB
Volume
24
Category
Article
ISSN
0724-8741

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📜 SIMILAR VOLUMES


Simultaneous versus sequential pharmacok
✍ Johannes H. Proost; Sjouke Schiere; Douglas J. Eleveld; J. Mark K. H. Wierda 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 231 KB

## Abstract A method for simultaneous pharmacokinetic‐pharmacodynamic (PK‐PD) population analysis using an Iterative Two‐Stage Bayesian (ITSB) algorithm was developed. The method was evaluated using clinical data and Monte Carlo simulations. Data from a clinical study with rocuronium in nine anest