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Performance of an Iterative Two-Stage Bayesian Technique for Population Pharmacokinetic Analysis of Rich Data Sets

✍ Scribed by Johannes H. Proost; Douglas J. Eleveld

Book ID: 106492929
Publisher: Springer US
Year: 2006
Tongue: English
Weight: 453 KB
Volume: 23
Category: Article
ISSN: 0724-8741
DOI: 10.1007/s11095-006-9116-0

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## Abstract A method for simultaneous pharmacokinetic‐pharmacodynamic (PK‐PD) population analysis using an Iterative Two‐Stage Bayesian (ITSB) algorithm was developed. The method was evaluated using clinical data and Monte Carlo simulations. Data from a clinical study with rocuronium in nine anest