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Peptoid residues and β-turn formation

✍ Scribed by Mario Rainaldi; Vittorio Moretto; Marco Crisma; Evaristo Peggion; Stefano Mammi; Claudio Toniolo; Giorgio Cavicchioni

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
183 KB
Volume
8
Category
Article
ISSN
1075-2617

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✦ Synopsis

Abstract

A set of terminally protected tripeptoids containing a residue of either N‐methylglycine or N‐__iso__butylglycine in position i + 1/i + 2 were synthesized and tested for intramolecularly H‐bonded β‐turn formation. By exploiting FT‐IR absorption and ^1^H NMR techniques, their folding tendencies were compared with those of a variety of reference peptides. The amount of β‐turn induction and the relative extent of the various types of intramolecularly H‐bonded β‐turn conformers were determined in chloroform solution. Copyright © 2002 European Peptide Society and John Wiley & Sons, Ltd.

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