𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Stabilizing effects of 2-methylalanine residues on β-turns and α-helices

✍ Scribed by G. Jung; R. Bosch; E. Katz; H. Schmitt; K.-P. Voges; W. Winter

Publisher
Wiley (John Wiley & Sons)
Year
1983
Tongue
English
Weight
255 KB
Volume
22
Category
Article
ISSN
0006-3525

No coin nor oath required. For personal study only.

✦ Synopsis

An N-terminal rigid a-helical segment is found in the polypeptide antibiotics alamethicin, suzukacillin, and trichotoxin. The a-helix dipole is essential for their voltage-dependent pore formation in lipid bilayer membranes, which is explained by a flip-flop gating mechanism based on dipole-dipole interactions of parallel and antiparallel arranged a-helices within oligomeric structures.

📜 SIMILAR VOLUMES

Effects of net charge and the number of
Effects of net charge and the number of positively charged residues on the biological activity of amphipathic α-helical cationic antimicrobial peptides
✍ Ziqing Jiang; Adriana I. Vasil; John D. Hale; Robert E. W. Hancock; Michael L. V 📂 Article 📅 2007 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 498 KB 👁 1 views

## Abstract In our previous study, we utilized a 26‐residue amphipathic α‐helical antimicrobial peptide L‐V13K (Chen et al., Antimicrob Agents Chemother 2007, 51, 1398–1406) as the framework to study the effects of peptide hydrophobicity on the mechanism of its antimicrobial action. In this study,

Effects of i and i+3 residue identity on
Effects of i and i+3 residue identity on Cis–Trans isomerism of the aromatici+1–prolyli+2 amide bond: Implications for type VI β-turn formation
✍ Hai Yun Meng; Krista M. Thomas; Aaron E. Lee; Neal J. Zondlo 📂 Article 📅 2006 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 310 KB

## Abstract __Cis__–__trans__ isomerization of amide bonds plays critical roles in protein molecular recognition, protein folding, protein misfolding, and disease. Aromatic–proline sequences are particularly prone to exhibit __cis__ amide bonds. The roles of residues adjacent to a tyrosine–proline

Differential in vivo effects of α-naphth
Differential in vivo effects of α-naphthoflavone and β-naphthoflavone on CYP1A1 and CYP2E1 in rat liver, lung, heart, and kidney
✍ Christopher J. Sinal; Christopher D. Webb; John R. Bend 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 225 KB 👁 1 views

Male Sprague-Dawley rats were treated intraperitoneally with corn oil, the aryl hydrocarbon receptor (AHR) agonist b-naphthoflavone (bNF), or the relatively weak AHR agonist ␣-naphthoflavone (␣NF). Animals treated with bNF experienced a significant loss (12%) of total body mass over 5 days and a dra