✦ LIBER ✦

Peptide related drug research : Josef Rudinger Memorial Lecture 2002

✍ Scribed by Professor Sándor Bajusz

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 157 KB
Volume: 9
Category: Article
ISSN: 1075-2617
DOI: 10.1002/psc.453

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✦ Synopsis

Abstract

Drug discovery directed peptide research has been pursued at the IVAX Drug Research Institute (formerly Institute for Drug Research) (IDR) since the mid 1950s. Outlined are the main projects and the most significant results, which include the first synthesis of human ACTH, the discovery of GYKI‐14 166, the prototype of peptide inhibitors of thrombin, a stable anticoagulant, efegatran GYKI‐14 766, and their dual acting analogues. The identification of an agonist analogue of LHRH leading to Cetrorelix, an LHRH antagonist now in clinical use, is also presented. Copyright © 2003 European Peptide Society and John Wiley & Sons, Ltd.

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