Peptide Receptors, Part II, Volume 20

✍ Scribed by A. Bjorklund, T. Hokfelt, P. Quinton

• Publisher: Elsevier Science
• Year: 2002
• Tongue: English
• Leaves: 441
• Series: Handbook of Chemical Neuroanatomy) (Pt. II
• Edition: 1
• Category: Library

✦ Synopsis

Peptide Receptors Part I was published in 2000 (as volume 16 of the Handbook of Chemical Neuroanatomy series). This volume summarized current knowledge on the discrete anatomical distribution of ten families of neuropeptide receptors expressed in the mammalian CNS. Part II is its natural complement
with chapters covering six additional families of neuropeptide receptors for ligands ranging from well known peptides such as the opioids and neurotensin to recently isolated ones like the orexins. As in the case of Part I, this volume integrates photomontages and maps of quantitative receptor autoradiography, in situ hybridization histochemistry and immunocytochemistry.

Data derived from transgenic and knock-out animals are also summarized, helping to decipher the possible physiological and Pathophysiological role(s) of a given peptide family. Some chapters also review current knowledge on the profile of internalization of the neuropeptide-receptor complex, an area of intense research activities that should help to better understand mechanisms involved in desensitization and tachyphylaxis.



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✦ Table of Contents

Front Cover......Page 1
Peptide Receptors......Page 4
Copyright Page......Page 5
Contents......Page 10
List of Contributors......Page 6
Preface......Page 8
2. Opioids......Page 18
3. Opioid receptor subtypes......Page 21
4. Distribution of opioid receptors in the rat brain......Page 25
6. Abbreviations......Page 39
8. References......Page 41
1. A survey of the melanin-concentrating system: seminal background studies and pharmaceutical interest......Page 48
2. The pro-MCH gene, regulation of expression and precursor processing......Page 53
3. Features of the MCH system in the rat CNS......Page 56
4. Central effects of MCH......Page 63
5. The MCH receptors......Page 67
6. Conclusion......Page 102
7. Abbreviations......Page 103
9. References......Page 109
1. Introduction......Page 120
2. General characteristics......Page 121
3. Biological effects of OFQ binding at the ORL1 receptor......Page 122
4. Anatomical studies of the orphanin peptide–receptor system......Page 123
5. In situ hybridization and immunohistochemistry studies......Page 124
6. Anatomical studies using 125I-[14Tyr]OFQ binding and agonist stimulated [35S]GTPγS receptor autoradiography......Page 161
7. Ontogeny studies......Page 172
8. Physiological implications of OFQ and the ORL1 receptor......Page 182
10. Abbreviations......Page 191
12. References......Page 201
2. Galanin......Page 212
3. Galanin receptor subtypes......Page 220
4. Localization of galanin receptors in the rat CNS......Page 225
5. Expression of GALRs by glial cells......Page 245
7. Localization of galanin receptors in dorsal root ganglia of the rat......Page 246
8. Concluding remarks......Page 248
9. Abbreviations......Page 250
10. Acknowledgements......Page 252
11. References......Page 253
1. Introduction......Page 262
2. Biology of orexins......Page 264
3. Orexin receptors......Page 269
4. Distribution of orexin receptor mRNA and protein in mammalian central nervous system......Page 274
5. Comparison of OX1R and OX2R distribution......Page 280
8. How many orexin receptors?......Page 329
9. Physiological and pathophysiological implications of orexin receptors......Page 330
11. Abbreviations......Page 332
13. References......Page 337
2. Discovery of NT......Page 340
4. Central effects of NT......Page 344
5. NT receptors in mammalian CNS......Page 345
6. Summary and conclusions......Page 400
7. Abbreviations......Page 401
9. References......Page 404
Subject Index......Page 418