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Peptide Receptors

✍ Scribed by R. Quirion, A. Björklund and T. Hökfelt (Eds.)

Publisher
Elsevier Science
Year
2000
Leaves
539
Series
Handbook of Chemical Neuroanatomy 16
Edition
1
Category
Library
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✦ Synopsis

During the last few years, the pace of research in the field of neuropeptide receptors has increased steadily: new neuropeptides were discovered, and the classification of receptor subtypes has been refined. It thus appeared essential to update the information. Peptide Receptors Part I summarizes current knowledge on ten distinct peptide families.
This volume integrates photomontages and maps of quantitative receptor autoradiography, in situ hybridization histochemistry, and immunocytochemistry images. Application of these classical techniques and of new approaches such as transgenic and knock-out animals has revealed a distinct species and tissue specific variation in receptor subtypes expression and pharmacology in the mammalian central nervous system.
The functional role of neuropeptides and their receptors in the CNS has been investigated thanks to the development of potent and selective receptor antagonists and agonists. The development of specific neuropeptide-related molecules will help to get a better understanding of receptor subtype physiology and neuronal distribution and may lead to innovative treatments in a variety of brain disorders.

✦ Table of Contents

Content:
List of contributors
Pages v-viii

Preface
Page ix
Rémi Quirion, Anders Björklund, Tomas Hökfelt

Chapter I Somatostatin receptors Original Research Article
Pages 1-43
P. Dournaud, A. Slama, A. Beaudet, J. Epelbaum

Chapter II Brain PACAP/VIP receptors: regional distribution, functional properties and physiological relevance Original Research Article
Pages 45-77
P.J. Magistretti, L. Journot, J. Bockaert, J.-L. Martin

Chapter iii Localization of angiotensin receptors in the nervous system Original Research Article
Pages 79-124
A.M. Allen, B.J. Oldfield, M.E. Giles, G. Paxinos, M.J. Mckinley, F.A.O. Mendelsohn

Chapter IV Brain endothelin and natriuretic peptide receptors Original Research Article
Pages 125-162
J.M. Saavedra, A.M. De Oliveira, O. JÖhren, L. Tonelli

Chapter V Neuropeptide FF receptors Original Research Article
Pages 163-193
J.-M. Zajac, C. Gouardères

Chapter VI Neurokinin receptors in the CNS Original Research Article
Pages 195-240
A. Ribeiro-da-silva, A.L. McLeod, J.E. Krause

Chapter VII Brain kallikrein–kinin system: from receptors to neuronal pathways and physiological functions Original Research Article
Pages 241-300
R. Couture, C.J. Lindsey

Chapter viii calcitonin gene-related peptide (cgrp), amylin and adrenomedullin: anatomical localization and biological functions in the mammalian and human brains Original Research Article
Pages 301-374
D. Jacques, Y. Dumont, D. Van rossum, R. Quirion

Chapter IX Neuropeptide Y, peptide YY and pancreatic polypeptide receptor proteins and mRNAs in mammalian brains Original Research Article
Pages 375-475
Y. Dumont, D. Jacques, J.-A. St-Pierre, Y. Tong, R. Parker, H. Herzog, R. Quirion

CHAPTER X Multiple brain corticotropin-releasing factor receptors and binding protein Original Research Article
Pages 477-508
E.B. De Souza, D.E. Grigoriadis

Subject index
Pages 509-517

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