Peptide receptors in astroglia: Focus on angiotensin II and atrial natriuretic peptide

✍ Scribed by Dr. Colin Sumners; Wei Tang; Waltke Paulding; Mohan K. Raizada

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 828 KB
• Volume: 11
• Category: Article
• ISSN: 0894-1491
• DOI: 10.1002/glia.440110206

✦ Synopsis

Astroglial cells derived from the mammalian central nervous system contain a wide variety of peptide receptors, including specific sites for angiotensin I1 (All) and atrial natriuretic peptide (ANP). The A11 receptors present in these cells are primarily of the AT, subtype. The ANP receptors present in these cells consist of a mix of ANP-A and ANP-B sites ("biological receptors") and also ANP-C sites ("clearance receptors"). Available evidence indicates that activation of AII receptors results in a stimulation of astroglial proliferation, whereas ANP has an antiproliferative effect in these cells. Intracellular pathways which may mediate these effects of A11 and ANP on cell proliferation are discussed, including the presentation of novel data on the activation of protein kinase C and of glucose uptake by AII. We also consider the possibility that the opposing actions of A11 and ANP on astroglial proliferation may represent another facet of the mutual antagonism between these two peptides, which has been observed throughout mammalian systems.