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Peptide peak intensities enhanced by cysteine modifiers and MALDI TOF MS

✍ Scribed by Zabet-Moghaddam, Masoud; Shaikh, Aarif L.; Niwayama, Satomi

Book ID: 118763035
Publisher: John Wiley and Sons
Year: 2012
Tongue: English
Weight: 283 KB
Volume: 47
Category: Article
ISSN: 1076-5174
DOI: 10.1002/jms.3093

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## Abstract The tau protein plays an important role in some neurodegenerative diseases including Alzheimer's disease (AD). Neurofibrillary tangles (NFTs), a biological marker for AD, are aggregates of bundles of paired helical filaments (PHFs). In general, the α‐sheet structure favors aberrant prot