Peptide Nucleic Acid. A Molecule with Two Identities
β Scribed by Nielsen, Peter E.
- Book ID
- 120560636
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 99 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0001-4842
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π SIMILAR VOLUMES
## Abstract Peptide nucleic acid (PNA) is a nucleobase oligomer in which the entire backbone has been replaced by a backbone composed of __N__β(2βaminoethyl)glycine units. In other words, PNA can be regarded as DNA with a neutral peptide backbone instead of a negatively charged sugarβphosphate back
A novel class of chiral peptide nucleic acids has been synthesized in which the sugarphosphate backbone of DNA has been replaced with the glycyl-proline backbone of both the L-and the D-configurations, nucleobases being attached through the 4-position of proline with cis-and trans-stereochemistry. T