Peptide N-alkylamides by solid phase synthesis*
✍ Scribed by KORNREICH, WAYNE ;ANDERSON, HARRY ;PORTER, JOHN ;VALE, WYLIE ;RIVIER, JEAN
- Book ID
- 115098321
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 461 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0367-8377
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📜 SIMILAR VOLUMES
## Abstract The __N__‐tetrachlorophthaloyl‐(TCP‐)amino protecting group has been evaluated for use in solid‐phase peptide synthesis. The TCP group was unaffected by exposure to either piperidine or __N__,__N__‐diisopropylethylamine (DIEA), which suggests compatibility with both Fmoc and Boc solid‐p
The use ofnucleophiles for the cleavage of an o-nitrobenzylester peptide-resin bond in order to afford peptide alkylesters and alkylamides has been studied. With this purpose, three short peptide sequences anchored to a Nbb-resin were used as models. Peptides were cleaved from the polymeric supports