N-Linked solid phase peptide synthesis
✍ Scribed by Roger Le´ger; Rose Yen; Miles W. She; Ving J. Lee; Scott J. Hecker
- Book ID
- 108386797
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 218 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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A solid phase synthesis method for a cystine-linked peptide-PNA chimera starting from different modified protected cystine monomers was developed. This strategy dramatically improved the final yield and the specificity of disulphide bond formation in this kind of oligomers, which are traditionally o
## Abstract The __N__‐tetrachlorophthaloyl‐(TCP‐)amino protecting group has been evaluated for use in solid‐phase peptide synthesis. The TCP group was unaffected by exposure to either piperidine or __N__,__N__‐diisopropylethylamine (DIEA), which suggests compatibility with both Fmoc and Boc solid‐p