Peptide mimics of epidermal growth factor (EGF) with antagonistic activity
β Scribed by Takashi Nakamura; Hiroshi Takasugi; Tomoyasu Aizawa; Masanobu Yoshida; Mineyuki Mizuguchi; Yoshihiro Mori; Hiroyuki Shinoda; Yoichi Hayakawa; Keiichi Kawano
- Book ID
- 118471237
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 135 KB
- Volume
- 116
- Category
- Article
- ISSN
- 0168-1656
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## Abstract The capacity of cultured human fibroblasts to bind ^125^Iβlabeled epidermal growth factor (EGF) was measured during protein synthesis inhibition and reinitiation. Protein synthesis was inhibited by incubation of human fibroblasts in histidineβfree medium supplemented with Lβhistidinol t
Normal rat kidney (NRK) fibroblasts are immortalized cells that are strictly dependent on externally added growth factors for proliferation. When cultured in the presence of epidermal growth factor (EGF) as the only growth stimulating hormone, these cells have a normal phenotype and undergo density-