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Peptide derivatives related to the active site of some hydrolytic enzymes: IV. Tetrapeptide derivatives containing D-serine

✍ Scribed by H. Kienhuis; J. P. J. van der Holst; A. Verweij

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
163 KB
Volume
88
Category
Article
ISSN
0165-0513

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## Abstract The syntheses of glycyl‐α‐L‐glutamyl‐L‐serylglycine ethyl ester and of glycyl‐α‐L‐glutamyl‐O‐acetyl‐L‐serylglycine ethyl ester are described. The mixed anhydride method and the carbodiimide method were used for condensing together two dipeptide derivatives. The latter were obtained by t

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## Abstract The syntheses are described of glycyl‐α‐L‐aspartyl‐L‐serylglycine ethyl ester and of the O‐acetylated derivative. The tetrapeptide ethyl esters were obtained by coupling two dipeptide derivatives using the mixed anhydride method, followed by removal of the blocking groups. The dipeptide