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Peptide derivatives related to the active site of some hydrolytic enzymes: II. Syntheses of tetrapeptide ethyl esters containing aspartic acid and serine

✍ Scribed by A. van De Linde; H. Kienhuis; A. Verweij; J. P. J. van der Holst

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
251 KB
Volume
80
Category
Article
ISSN
0165-0513

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✦ Synopsis

Abstract

The syntheses are described of glycyl‐α‐L‐aspartyl‐L‐serylglycine ethyl ester and of the O‐acetylated derivative. The tetrapeptide ethyl esters were obtained by coupling two dipeptide derivatives using the mixed anhydride method, followed by removal of the blocking groups. The dipeptide derivatives were synthesised by the azide method.

📜 SIMILAR VOLUMES

Peptide derivatives related to the activ
Peptide derivatives related to the active site of some hydrolytic enzymes: I. Syntheses of tetrapeptide ethyl esters containing glutamic acid and serine
✍ H. Kienhuis; A. van De Linde; J. P. J. van Der Holst; A. Verweij 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 380 KB

## Abstract The syntheses of glycyl‐α‐L‐glutamyl‐L‐serylglycine ethyl ester and of glycyl‐α‐L‐glutamyl‐O‐acetyl‐L‐serylglycine ethyl ester are described. The mixed anhydride method and the carbodiimide method were used for condensing together two dipeptide derivatives. The latter were obtained by t