Peptide-dependent recognition of H–2Kb by alloreactive cytotoxic T lymphocytes
✍ Scribed by Heath, William R.; Hurd, Melissa E.; Carbone, Francis R.; Sherman, Linda A.
- Book ID
- 109761552
- Publisher
- Nature Publishing Group
- Year
- 1989
- Tongue
- English
- Weight
- 458 KB
- Volume
- 341
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/341749a0
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Cytotoxic T lymphocytes (CTLs) cause specific destruction of allografts and viral-infected cells. While viral-restricted CTLs recognize viral peptides in association with class-I molecules encoded in the major histocompatibility complex, the role which peptides play during allorecognition remains ob
## Cell-type-specific recognition of allogeneic cells by alloreactive cytotoxic T cells: a consequence of peptide-dependent allorecognition* Recently, we provided the first direct evidence that the determinant recognized by some alloreactive cytotoxicT lymphocytes (CTL) clones included an endogeno
The molecular basis of the recognition of class-I HLA antigens by allo-reactive cytotoxic T lymphocytes (CTL) remains obscure. This article reviews our work in which HLA-B27-specific allo-reactive CTL clones were obtained and their fine specificity was analyzed with a panel of structurally defined H