Peptide chemistry applied to a new family of phenothiazine-containing inhibitors of human farnesyltransferase
✍ Scribed by Dumitriu, Gina-Mirabela; Ghinet, Alina; Bîcu, Elena; Rigo, Benoît; Dubois, Joëlle; Farce, Amaury; Belei, Dalila
- Book ID
- 122140110
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 1020 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0960-894X
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A new family of 3-amino-1,2-henzisoxazoles was designed and synthesized to be a potent inhibitors of LTB4 binding to the human neutrophils. HS-1141 appears to be one of the strongest inhibitors of LTB4 binding reported so far (IC50 = 7nM).
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