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3-Amino-1,2-benzisoxazoles: A new family of potent inhibitors of LTB4 binding to the human neutrophils

✍ Scribed by Hongsuk Suh; Soo-Jeong Jeong; Yong Nam Han; Hwa-Jin Lee; Jae-Ha Ryu

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 228 KB
Volume: 7
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(97)00025-5

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✦ Synopsis

A new family of 3-amino-1,2-henzisoxazoles was designed and synthesized to be a potent inhibitors of LTB4 binding to the human neutrophils. HS-1141 appears to be one of the strongest inhibitors of LTB4 binding reported so far (IC50 = 7nM).

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