Peptide-Based Drug Design
β Scribed by Laszlo Otvos Jr. (auth.), Laszlo Otvos (eds.)
- Publisher
- Humana Press
- Year
- 2008
- Tongue
- English
- Leaves
- 310
- Series
- Methods In Molecular Biology 494
- Edition
- 1
- Category
- Library
No coin nor oath required. For personal study only.
β¦ Synopsis
Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. In Peptide-Based Drug Design: Methods and Protocols, expert researchers provide a handbook which offers a selection of research and production tools suitable for transforming a promising protein fragment or stand-alone native peptide into a pharmaceutically acceptable composition. The volume delves into contemporary, cutting-edge subjects such as hit isolation and target validation, computer-aided design, sequence modifications to satisfy pharmacologists, in vivo stability and imaging, and the actual production of difficult sequences. Written in the highly successful Methods in Molecular Biologyβ’ series format, chapters include readily reproducible, step-by-step laboratory protocols, lists of materials, and the Notes section, which highlights tips on troubleshooting and avoiding known pitfalls.
Comprehensive and up-to-date, Peptide-Based Drug Design: Methods and Protocols shows its subject to be an independent science on the rise, and provides scientists with a clear, concise guide for continuing this vital research.
β¦ Table of Contents
Front Matter....Pages i-xi
Back Matter....Pages 1-8
....Pages 9-29
β¦ Subjects
Pharmacology/Toxicology; Medicinal Chemistry
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<p><P>Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. In <EM>Peptide-Based Drug Design: Methods and Protocols</EM>, expert researchers provide a handbook which offers a selection of research and production tools suitabl
This book focuses on peptides as drugs, a growing area of pharmaceutical research and development. It helps readers solve problems of discovering, developing, producing, and delivering peptide-based drugs. * Identifies promising new areas in peptide drug discovery * Includes chapters on discovery f
<P>With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. </P><br /><P>
<p>This brief describes studies conducted by the authors on mid-size drugs utilizing peptides and peptidomimetics, and on the development of anti-HIV agents. Peptides are important biological molecules and have various physiological actions. Peptide-based drug discovery may help bring about the deve
This brief describes studies conducted by the authors on mid-size drugs utilizing peptides and peptidomimetics, and on the development of anti-HIV agents. Peptides are important biological molecules and have various physiological actions. Peptide-based drug discovery may help bring about the develop