Mid-size Drugs Based on Peptides and Peptidomimetics: A New Drug Category

✍ Scribed by Hirokazu Tamamura,Takuya Kobayakawa,Nami Ohashi (auth.)

• Publisher: Springer Singapore
• Year: 2018
• Tongue: English
• Leaves: 113
• Series: SpringerBriefs in Pharmaceutical Science & Drug Development
• Edition: 1
• Category: Library

✦ Synopsis

This brief describes studies conducted by the authors on mid-size drugs utilizing peptides and peptidomimetics, and on the development of anti-HIV agents. Peptides are important biological molecules and have various physiological actions. Peptide-based drug discovery may help bring about the development of useful medicines that are highly safe and show potent pharmacological effects in small doses. Recently, it has been shown that there is an important drug-like space in the mid-sized region between low- and high-molecular-weight compounds. Thus, mid-size drugs such as peptide compounds are being focused on. To date, several peptidomimetics that mimic primary, secondary, and tertiary structures of peptides have been developed to maintain and improve biological activities and actions of peptides. In this book, the features and advantages of mid-size drugs are described in detail. In addition, the merits of utilizing peptidomimetics in the development of mid-size drugs are referred to. Understanding such peptide-derived mid-size drugs will lead to a comprehensive expansion of medicinal chemistry.

✦ Table of Contents

Front Matter ....Pages i-xvii
Introduction to Mid-size Drugs and Peptidomimetics (Hirokazu Tamamura, Takuya Kobayakawa, Nami Ohashi)....Pages 1-16
Chloroalkene Dipeptide Isosteres as Peptidomimetics (Hirokazu Tamamura, Takuya Kobayakawa, Nami Ohashi)....Pages 17-47
Conformational-Restricted Cyclic Peptides (Hirokazu Tamamura, Takuya Kobayakawa, Nami Ohashi)....Pages 49-63
Peptidomimetics That Mimic the Secondary Structures of Peptides (Hirokazu Tamamura, Takuya Kobayakawa, Nami Ohashi)....Pages 65-70
Peptidomimetics That Mimic the Tertiary Structures of Peptides (Hirokazu Tamamura, Takuya Kobayakawa, Nami Ohashi)....Pages 71-78
Conjugated Compounds Involving Peptides (Hirokazu Tamamura, Takuya Kobayakawa, Nami Ohashi)....Pages 79-95
Summary and Future Perspectives of Researches on Mid-size Drugs (Hirokazu Tamamura, Takuya Kobayakawa, Nami Ohashi)....Pages 97-100

✦ Subjects

Medicinal Chemistry