## Abstract __αβ__ T‐cell receptors (TCRs) recognize peptide antigens presented by class I or class II major histocompatibility complex molecules (pMHC). Here we review the use of thermodynamic measurements in the study of TCR–pMHC interactions, with attention to the diversity in binding thermodyna
Peptide Antagonism and T Cell Receptor Interactions with Peptide-MHC Complexes
✍ Scribed by Yuri Sykulev; Yulia Vugmeyster; Anders Brunmark; Hidde L. Ploegh; Herman N. Eisen
- Book ID
- 117722965
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 140 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1074-7613
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📜 SIMILAR VOLUMES
Antigen-specific T-cell activation requires the formation of a transient cell-cell conjugate between a T cell and an appropriate antigen presenting cell (APC). Focal aggregation of T-cell receptor (TCR) molecules at the T-cell-APC membrane interface accompanies formation of multiple non-covalent int
Fifteen years have passed since T-cell receptor (TCR) genes were identified (reviewed in [1]). Unlike the situation for antibodies, no direct structural information on the TCR proteins has been available for most of this time. Recently, however, the crystal structures of isolated (z and ~ chains wer