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Peptide Aldehyde Inhibitors of Cathepsin K Inhibit Bone Resorption Both In Vitro and In Vivo

✍ Scribed by Bartholomew J. Votta; Mark A. Levy; Alison Badger; Jeremy Bradbeer; Robert A. Dodds; Ian E. James; Scott Thompson; Mary J. Bossard; Thomas Carr; Janice R. Connor; Thaddeus A. Tomaszek; Lawrence Szewczuk; Fred H. Drake; Daniel F. Veber; Maxine Gowen


Book ID
111486156
Publisher
American Society for Bone and Mineral Research
Year
1997
Tongue
English
Weight
666 KB
Volume
12
Category
Article
ISSN
0884-0431

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Objective. Inhibitors of prostaglandin production, such as nonsteroidal antiinflammatory drugs (NSAIDs), and pharmacologic nitric oxide (NO) donors, such as organic nitrates, have been suggested to protect against bone loss in both humans and experimental animals. Recently, a new class of nitrosylat