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Inhibition of both class I and class II histone deacetylases is required to effectively inhibit osteoclast bone resorption in vivo and in vitro

✍ Scribed by M.D. Cantley; D.P. Fairlie; M.P. Bartold; K.D. Rainsford; D.R. Haynes


Book ID
116321395
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
70 KB
Volume
44
Category
Article
ISSN
8756-3282

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Histone deacetylase inhibitors (HDACi) suppress cancer cell growth, inflammation, and bone resorption. The aim of this study was to determine the effect of inhibitors of different HDAC classes on human osteoclast activity in vitro. Human osteoclasts generated from blood mononuclear cells stimulated