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Pentapeptide Amides Interfere with the Aggregation of β-Amyloid Peptide of Alzheimer's Disease

✍ Scribed by Csaba Hetényi; Zoltán Szabó; Éva Klement; Zsolt Datki; Tamás Körtvélyesi; Márta Zarándi; Botond Penke

Book ID
115589781
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
248 KB
Volume
292
Category
Article
ISSN
0006-291X

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✍ Harry Levine III 📂 Article 📅 2008 🏛 Cold Spring Harbor Laboratory Press 🌐 English ⚖ 611 KB

## Abstract Thioflavine T (ThT) associates rapidly with aggregated fibrils of the synthetic __β__/A4‐derived peptides __β__(1–28) and __β__(1–40), giving rise to a new excitation (ex) (absorption) maximum at 450 nm and enhanced emission (em) at 482 nm, as opposed to the 385 nm (ex) and 445 nm (em)