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Penetrances of breast and ovarian cancer in a large series of families tested for BRCA1/2 mutations

โœ Scribed by Marroni, Fabio; Aretini, Paolo; D'Andrea, Emma; Caligo, Maria Adelaide; Cortesi, Laura; Viel, Alessandra; Ricevuto, Enrico; Montagna, Marco; Cipollini, Giovanna; Federico, Massimo


Book ID
110025661
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
140 KB
Volume
12
Category
Article
ISSN
1018-4813

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Germline mutations of BRCA1 and BRCA2 in
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Germline mutations in the BRCA1 and BRCA2 genes are responsible for the predisposition and development of familial breast and/or ovarian cancer. Most mutations of BRCA1 and BRCA2 associated with breast and/or ovarian cancer result in truncated proteins. To investigate the presence of BRCA1 and BRCA2