Pedigree transmission disequilibrium test for QTL mapping of threshold trait
โ Scribed by Xiangdong Ding; Qin Zhang; Ruhai Xu; Yachun Wang
- Book ID
- 111784816
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 382 KB
- Volume
- 49
- Category
- Article
- ISSN
- 1001-6538
- DOI
- 10.1360/04wc0050
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## Abstract Allison ([1997] Am. J. Hum. Genet. 60:676โ690) proposed four versions of the transmissionโdisequilibrium test (TDT) for quantitative traits when there is __extremeโthreshold sampling__, i.e., the trios having an offspring trait value between a priori defined thresholds are excluded from
## Abstract This paper presents a unified framework for transmissionโdisequilibrium tests for discrete and continuous traits. A conditional score test is derived that maximizes power to detect small effects for any exponential family distribution, which includes binary and normal distributions, and