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PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein is essential for the interleukin 2 independent growth induction of a T-cell line

✍ Scribed by Chikako Tsubata; Masaya Higuchi; Masahiko Takahashi; Masayasu Oie; Yuetsu Tanaka; Fumitake Gejyo; Masahiro Fujii


Book ID
119907656
Publisher
BioMed Central
Year
2005
Tongue
English
Weight
336 KB
Volume
2
Category
Article
ISSN
1742-4690

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## Abstract Our aim was to examine the involvement of G~1~ cell‐cycle regulators in cell growth dysregulation induced by HTLV‐I. Compared to uninfected cells, higher expression levels of cyclin D1 and D2 mRNA were detected in HTLV‐I–infected T‐cell lines, which were at least in part mediated by the