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Activation of mTOR by human T-cell leukemia virus type 1 Tax is important for the transformation of mouse T cells to interleukin-2-independent growth

✍ Scribed by Manami Yoshita; Masaya Higuchi; Masahiko Takahashi; Masayasu Oie; Yuetsu Tanaka; Masahiro Fujii


Book ID
114703110
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
337 KB
Volume
103
Category
Article
ISSN
1347-9032

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## Abstract Our aim was to examine the involvement of G~1~ cell‐cycle regulators in cell growth dysregulation induced by HTLV‐I. Compared to uninfected cells, higher expression levels of cyclin D1 and D2 mRNA were detected in HTLV‐I–infected T‐cell lines, which were at least in part mediated by the