## Abstract Platelet‐derived growth factor (PDGF) has been implicated in smooth muscle cell (SMC) proliferation, a key event in the development of myointimal hyperplasia in vascular grafts. Recent evidence suggests that the PDGF receptor (PDGFR) tyrosine kinase inhibitor, imatinib, can prevent arte
✦ LIBER ✦
PDGF-receptor-β antisense gene transfer decreases proliferation and PDGF binding of human primary smooth muscle cells
✍ Scribed by A.-M. Turunen; A. Krettek; F. Lustig; G. Bondjers; S. Ylä-Herttuala
- Book ID
- 119434655
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 134 KB
- Volume
- 151
- Category
- Article
- ISSN
- 0021-9150
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Endothelial cells (ECs) and smooth muscle cells (SMCs), which are the major component cells of blood vessels, produce various bioactive substances and communicate with each other through them. Although several studies of the interaction between ECs and SMCs have been reported, the eect of coculture