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PDGF-like growth factors in autocrine stimulation of growth

✍ Scribed by Carl-Henrik Heldin; Bengt Westermark

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
389 KB
Volume
133
Category
Article
ISSN
0021-9541

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✦ Synopsis

PDGF is a dimeric molecule consisting of A chains and B chains. All three dimeric combinations have been found in platelets, or produced by certain normal or transformed cell types; whether functional differences occur between different dimers is currently under investigation. Production of PDGF- like factors by cells carrying PDGF receptors may establish an autocrine loop, driving cell mu Iti plication.

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