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Pd–Cu catalyzed heterocyclization during Sonogashira coupling: synthesis of 2-benzylimidazo[1,2-a]pyridine

✍ Scribed by Mohammad Bakherad; Hossein Nasr-Isfahani; Ali Keivanloo; Nesa Doostmohammadi

Book ID
104095279
Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
112 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis

The reaction of 2-amino-1-(2-propynyl)pyridinium bromide with various iodobenzenes, catalyzed by Pd-Cu, leads to the formation of 2-benzylimidazo[1,2-a]pyridines.

📜 SIMILAR VOLUMES

Pd/C-catalyzed heterocyclization during
Pd/C-catalyzed heterocyclization during copper-free Sonogashira coupling: synthesis of 2-benzylimidazo[1,2-a]pyrimidines in water
✍ Mohammad Bakherad; Ali Keivanloo; Zahra Kalantar; Saeideh Jajarmi 📂 Article 📅 2011 🏛 Elsevier Science 🌐 French ⚖ 710 KB

An efficient synthesis of 2-benzylimidazo[1,2-a]pyrimidines in water is accomplished via Pd/C-catalyzed reaction of 2-imino-1-(2-propynyl)pyrimidine with various aryl iodides in the presence of K 2 CO 3 as the base.