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PDCD4 gene silencing in gliomas is associated with 5′CpG island methylation and unfavourable prognosis

✍ Scribed by Fei Gao; Xiaoyan Wang; Faliang Zhu; Qun Wang; Xia Zhang; Chun Guo; Chengjun Zhou; Chunhong Ma; Wensheng Sun; Yun Zhang; Youhai H. Chen; Lining Zhang

Book ID: 114778524
Publisher: Carol Davila University of Medicine Bucharest, Romania
Year: 2009
Tongue: English
Weight: 979 KB
Volume: 13
Category: Article
ISSN: 1582-1838
DOI: 10.1111/j.1582-4934.2008.00497.x

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## Abstract Rhabdomyosarcoma (RMS), the most common pediatric soft tissue sarcoma likely results from abnormal proliferation and differentiation during skeletal myogenesis. Multiple genetic alterations are associated with the three RMS histopathological subtypes, embryonal, alveolar, and pleomorphi