Pd(0)-catalyzed regio- and stereoselective cyclization of alkynes: selective synthesis of (E)-4-(isobenzofuran-1(3H)-ylidene)-1,2,3,4-tetrahydroisoquinolines and aze/oxepinoindoles
β Scribed by Nandakumar, Avanashiappan ;Kiruthika, Selvarangam E. ;Naveen, Kanagaraj ;Perumal, Paramasivan Thirumalai
- Book ID
- 121438997
- Publisher
- Royal Society of Chemistry
- Year
- 2014
- Tongue
- English
- Weight
- 430 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1477-0520
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π SIMILAR VOLUMES
## Abstract A general oneβpot Pdβcatalyzed synthesis of the target compounds (E)β3βarylideneβ1,4βbenzoxazines starts from inexpensive and readily available starting materials.
A stereocontrolled synthetic approach to E-and Z-substituted methylene-3,4-dihydro-2H-1-benzopyrans 5 is described from acyclic derivatives using as a key step the palladium-catalyzed intramolecular cyclic carbopalladation of iodoalkynes 4 followed by a carbonylation or a hydride ion capture process